PRODUCT DETAILS

About Coxcure Z Tablet

RIFAMPICIN+ISONIAZID+PYRAZINAMIDE belongs to the group of medicines called 'anti-tuberculosis drugs' primarily used to treat bacterial severe infection tuberculosis. Also known as TB, Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine, and bone marrow. RIFAMPICIN+ISONIAZID+PYRAZINAMIDE does not work against infections caused by the virus, including cold and flu.

Uses of Coxcure Z Tablet

Tuberculosis

Medicinal Benefits of Coxcure Z Tablet

RIFAMPICIN+ISONIAZID+PYRAZINAMIDE is a combination of three anti-tuberculosis drugs, namely: Rifampicin, Isoniazid, and Pyrazinamide. RIFAMPICIN+ISONIAZID+PYRAZINAMIDE belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat tuberculosis. Rifampicin inhibits DNA dependant RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, RIFAMPICIN+ISONIAZID+PYRAZINAMIDE kills Mycobacterium tuberculosis which causes TB (tuberculosis).

Directions for Use

Take RIFAMPICIN+ISONIAZID+PYRAZINAMIDE on an empty stomach, i.e., 30minutes before food or 2hours after food. Swallow RIFAMPICIN+ISONIAZID+PYRAZINAMIDE as a whole; do not crush or chew the tablet. The dose and duration of RIFAMPICIN+ISONIAZID+PYRAZINAMIDE can vary depending upon your condition and severity of the infection. Based on your condition, your doctor will decide how long you need to take RIFAMPICIN+ISONIAZID+PYRAZINAMIDE

Side Effects of Coxcure Z Tablet

• Weakness
• Nausea
• Vomiting
• Stomach pain
• Joint or muscle pain

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take RIFAMPICIN+ISONIAZID+PYRAZINAMIDE if you are allergic to any of its contents; if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting RIFAMPICIN+ISONIAZID+PYRAZINAMIDE, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE as they might cause interaction. Maintain a gap of one hour between RIFAMPICIN+ISONIAZID+PYRAZINAMIDE and antacid medicines. Consult your doctor before taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE if you are pregnant. Avoid breastfeeding while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE as it passes into breast milk. RIFAMPICIN+ISONIAZID+PYRAZINAMIDE is not recommended for use in children. RIFAMPICIN+ISONIAZID+PYRAZINAMIDE may cause dizziness, and vision problems, so drive with caution. Avoid alcohol consumption while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE as it could lead to increased liver damage. Keep your doctor informed about your health condition and all the medicines you are taking to rule out any interactions.

Drug Interactions

Drug-Drug Interaction:

RIFAMPICIN+ISONIAZID+PYRAZINAMIDE may have interaction with an antibiotic (erythromycin), pain killer (acetaminophen), anti-diabetic (insulin isophane), anti-HIV (saquinavir, ritonavir), supplement (ergocalciferol).

Drug-Disease Interaction:

 RIFAMPICIN+ISONIAZID+PYRAZINAMIDE may have interactions with colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, haemodialysis, diabetes, gout (high uric acid), liver toxicity, dialysis, optic neuritis (vision problems), kidney and liver dysfunction

Safety Advice

ALCOHOL

Avoid alcohol consumption while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE as it could lead to increased liver damage.

PREGNANCY

Please consult your doctor if you are pregnant, planning for pregnancy or think you are pregnant; your doctor will prescribe RIFAMPICIN+ISONIAZID+PYRAZINAMIDE only if the benefits outweigh the risks.

BREAST FEEDING

RIFAMPICIN+ISONIAZID+PYRAZINAMIDE passes into breast milk. Do not breastfeed while taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE.

DRIVING

RIFAMPICIN+ISONIAZID+PYRAZINAMIDE may cause dizziness, vision problems, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

LIVER

Dose adjustment may be needed. Please consult your doctor before taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE if you have liver impairment/liver disease before taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE.

KIDNEY

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking RIFAMPICIN+ISONIAZID+PYRAZINAMIDE.